Original AFL supports black-box coverage-guided fuzzing using QEMU mode. I highly recommend to try it first and if it doesn't work you can try this tool.

Usage
You need to specify DRRUN_PATH to point to drrun launcher and LIBCOV_PATH to point to libbinafl.so coverage library. You also need to switch off AFL's fork server (AFL_NO_FORKSRV=1) and probably AFL_SKIP_BIN_CHECK=1. See step 5 in the build section below for more details.
NOTE: Don't forget that you should use 64-bit DynamoRIO for 64-bit binaries and 32-bit DynamoRIO for 32-bit binaries, otherwise it will not work. To make sure that your target is running under DynamoRIO, you can run it using the following command:

drrun -- <path/to/your/app/> <app_args>

Instrumentation DLL
Instrumentation library is a modified version of winAFL's coverage library created by Ivan Fratric.

Build

Step 1. Clone drAFL repo

git clone https://github.com/mxmssh/drAFL.git /home/max/drAFL
 cd /home/max/drAFL

Step 2. Clone and build DynamoRIO

git clone https://github.com/DynamoRIO/dynamorio
 mkdir build_dr
 cd build_dr/
 cmake ../dynamorio/
 make -j
 cd ..

If you have any problems with DynamoRIO compilation check this page

Step 3. Build coverage tool

mkdir build
 cd build
 cmake ../bin_cov/ -DDynamoRIO_DIR=../build_dr/cmake
 make -j
 cd ..

Step 4. Build patched AFL

cd afl/
 make
 cd ..

Step 5. Configure environment variables and run the target

cd build
 mkdir in
 mkdir out
 echo "AAAA" > in/seed
 export DRRUN_PATH=/home/max/drAFL/build_dr/bin64/drrun
 export LIBCOV_PATH=/home/max/drAFL/build/libbinafl.so 
 export AFL_NO_FORKSRV=1
 export AFL_SKIP_BIN_CHECK=1
 ../afl/afl-fuzz -m 500 -i in -o out -- ./afl_test @@

In case of afl_test you should expect 25-30 exec/sec and 1 unique crash in 2-3 minutes.